Exposure for the glucuronide metabolite is 35 to 40 periods higher than exposure on the father or mother drug. In vitro knowledge counsel that hydromorphone in clinically relevant concentrations has negligible probable to inhibit the activity of human hepatic CYP450 enzymes which include CYP1A2, 2C9, 2C19, 2D6, 3A4, and 4A11.fentanyl transmucosal a